Fibroblast Growth Factor 21: A Versatile Regulator of Metabolic Homeostasis
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چکیده
منابع مشابه
Fibroblast Growth Factor 21: A Novel Metabolic Regulator
Fibroblast growth factor 21 (FGF21) is a novel metabolic regulator produced primarily by the liver that exerts potent antidiabetic and lipid-lowering effects in animal models of obesity and type 2 diabetes mellitus. This hormone contributes to body weight regulation and is strongly involved in the response to nutritional deprivation and ketogenic state in mice. The principal sites of metabolic ...
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Fibroblast growth factor (FGF) 21 is a member of the endocrine FGF subfamily. FGF21 expression is induced under different disease conditions, such as type 2 diabetes, obesity, chronic kidney diseases, and cardiovascular diseases, and it has a broad spectrum of functions in regulating various metabolic parameters. Many different approaches have been pursued targeting FGF21 and its receptors to d...
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Obesity, with its related problems, is recognized as the fastest growing disease epidemic facing the world, yet we still have limited insight into the regulation of adipose tissue mass in humans. We have previously shown that adipose-derived microvascular endothelial cells (MVECs) secrete a factor(s) that increases proliferation of human preadipocytes. We now demonstrate that coculture of human...
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For many patients, a mitochondrial disease diagnosis is often difficult to establish with certainty, except in cases with a classical clinical presentation. Invasive and time-consuming methods, such as tissue biopsy and enzymatic studies, are frequently necessary before proceeding to molecular genetic analyses, because of the low specificity and sensitivity of existing lessinvasive biomarkers, ...
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BACKGROUND One of the main challenges in skin flap surgery is tissue ischemia and following necrosis. The present study compares the effects of fibroblast growth factors 1 and 2 on increasing cutaneous vasculature, improving ischemia, and preventing distal necrosis in ischemic skin flaps in rat model. METHODS Thirty rats were allocated into 3 groups (n=10) and 2×8 cm dorsal rando...
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ژورنال
عنوان ژورنال: Annual Review of Nutrition
سال: 2018
ISSN: 0199-9885,1545-4312
DOI: 10.1146/annurev-nutr-071816-064800